CTAB-coated gold nanorods elicit allergic response through degranulation and cell death in human basophils.
نویسندگان
چکیده
The effect of CTAB (cetyltrimethylammonium bromide)- or PEG (polyethylene glycol)-coated gold-nanorods (Au-NRs) on the non-IgE mediated allergic response was studied. We found that the CTAB-Au-NRs released more allergic mediators such as histamine and β-hexosaminidase from human basophil KU812, a common model for studying allergy, after 20 min incubation. Also, the CTAB-Au-NRs induced more apoptosis than the PEG-Au-NRs in KU812 24 h after treatment. These short- and long-term effects were not solely due to the CTAB residues in the supernatant desorbed from the Au-NRs.
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ورودعنوان ژورنال:
- Nanoscale
دوره 4 15 شماره
صفحات -
تاریخ انتشار 2012